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Cross-species variant-to-function analyses implicate <i>MEIS1</i> in conferring sleep abnormalities and impaired cerebellar development

2025-08-06

Abstract excerpt

Genome wide association study (GWAS) reports substantially outpace subsequent functional characterization. Pinpointing the causal effector gene(s) at GWAS loci remains challenging given the non-coding genomic residency of >98% of these signals. We previously implicated effector genes at GWAS loci for the complex and polygenic disorder of human insomnia using a high-resolution cell-specific, chromatin capture-based...

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Literature Corpus work
43dad7ab-5f99-5b69-8a9f-b77175b38e7c
DOI
10.1101/2025.08.05.665539
Open publication

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Cross-species variant-to-function analyses implicate <i>MEIS1</i> in conferring sleep abnormalities and impaired cerebellar developmentDOI 10.1101/2025.08.05.665539
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