The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

doi:10.1093/brain/awy057

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Article

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

Brain : a journal of neurology - 1 May 2018

Galvan Laurie, Francelle Laetitia, Gaillard Marie-Claude, de Longprez Lucie, Carrillo-de Sauvage Maria-Angeles, Liot Géraldine, Cambon Karine, Stimmer Lev, Luccantoni Sophie, Flament Julien, Valette Julien, de Chaldée Michel, Auregan Gwenaelle, Guillermier Martine, Joséphine Charlène, Petit Fanny, Jan Caroline, Jarrige Margot, Dufour Noëlle, Bonvento Gilles, Humbert Sandrine, Saudou Frédéric, Hantraye Philippe, Merienne Karine, Bemelmans Alexis-Pierre, Perrier Anselme L, Déglon Nicole, Brouillet Emmanuel

Abstract excerpt

The neurobiological functions of a number of kinases expressed in the brain are unknown. Here, we report new findings on DCLK3 (doublecortin like kinase 3), which is preferentially expressed in neurons in the striatum and dentate gyrus. Its function has never been investigated. DCLK3 expression is markedly reduced in Huntington's disease. Recent data obtained in studies related to cancer suggest DCLK3 could have...

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Identifiers

PMID: 29534157
DOI: 10.1093/brain/awy057
PMCID: PMC5917821

Genes

DCLK3
TADA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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