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Article

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.

Human molecular genetics - 1 Jul 2003

Slow Elizabeth J, van Raamsdonk Jeremy, Rogers Daniel, Coleman Sarah H, Graham Rona K, Deng Yu, Oh Rosemary, Bissada Nagat, Hossain Sazzad M, Yang Yu-Zhou, Li Xiao-Jiang, Simpson Elizabeth M, Gutekunst Claire-Anne, Leavitt Blair R, Hayden Michael R

Abstract excerpt

An expanded CAG repeat is the underlying genetic defect in Huntington disease, a disorder characterized by motor, psychiatric and cognitive deficits and striatal atrophy associated with neuronal loss. An accurate animal model of this disease is crucial for elucidation of the underlying natural history of the illness and also for testing experimental therapeutics. We established a new yeast artificial chromosome...

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PMID: 12812983
DOI: 10.1093/hmg/ddg169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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