Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional correlates of the pathological phenotype in a Huntington's disease mouse model.

Scientific reports - 10 Dec 2019

Gallardo-Orihuela Andrea, Hervás-Corpión Irati, Hierro-Bujalance Carmen, Sanchez-Sotano Daniel, Jiménez-Gómez Gema, Mora-López Francisco, Campos-Caro Antonio, Garcia-Alloza Monica, Valor Luis M

Abstract excerpt

Huntington disease (HD) is a fatal neurodegenerative disorder without a cure that is caused by an aberrant expansion of CAG repeats in exon 1 of the huntingtin (HTT) gene. Although a negative correlation between the number of CAG repeats and the age of disease onset is established, additional factors may contribute to the high heterogeneity of the complex manifestation of symptoms among patients. This variability...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corpus Striatum
Share to Huntingtin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntington Disease

Share to Neostriatum

Share to Nerve Tissue Proteins

Share to Neurons

Share to Transcriptome

Share to Trinucleotide Repeat Expansion

Source

Open in PubMed Open full text

Identifiers

PMID: 31822756
DOI: 10.1038/s41598-019-55177-9
PMCID: PMC6904489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional correlates of the pathological phenotype in a Huntington's disease mouse model.PMID 31822756Read ↗

Comparative analysis of pathology and behavioural phenotypes in mouse models of Huntington's disease.Semantic proximity Read ↗

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.Semantic proximity Read ↗

Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomicsSemantic proximity Read ↗

Quantitative gene expression profiling of mouse brain regions reveals differential transcripts conserved in human and affected in disease modelsSemantic proximity Read ↗

High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.Semantic proximity Read ↗

Selective inhibition of histone deacetylase 1 and 3 improves motor phenotype and alleviates transcriptional dysregulation in Huntington’s disease miceSemantic proximity Read ↗

Transcriptional Dysregulation in the Hippocampus of a murine model for Parkinson’s Disease Cognition Impairment is Driven by Sex, Age, and Alpha-synuclein overexpressionSemantic proximity Read ↗

Dysregulation of gene expression in the striatum of BACHD rats expressing full-length mutant huntingtin and associated abnormalities on molecular and protein levels.Semantic proximity Read ↗

Expression analysis of Huntington disease mouse models reveals robust striatum disease signaturesSemantic proximity Read ↗

Single-cell transcriptomics and mouse model phenotyping for biomarker screen of peripheral blood in Huntington's disease.Semantic proximity Read ↗

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain.Semantic proximity Read ↗

Striatal specificity of gene expression dysregulation in Huntington's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.