Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative analysis of pathology and behavioural phenotypes in mouse models of Huntington's disease.

Brain research bulletin - 1 Jun 2012

Brooks Simon P, Jones Lesley, Dunnett Stephen B

Abstract excerpt

The longitudinal characterisation of Huntington's disease (HD) mouse lines is essential for the understanding of the differential developmental time course, nature and severity of phenotype progression over time. This overview outlines detailed behavioural, neuropathological and gene expression studies in four HD mouse lines: R6/1, YAC128, HdhQ92 and HdhQ150 and outlines their relevance to human HD. The review...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Disease Models, Animal
Share to Huntington Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Longitudinal Studies

Share to Mice, Mutant Strains

Share to Phenotype

Source

Identifiers

PMID: 22004616
DOI: 10.1016/j.brainresbull.2011.10.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative analysis of pathology and behavioural phenotypes in mouse models of Huntington's disease.PMID 22004616Read ↗

Mouse Models of Huntington's Disease.Semantic proximity Read ↗

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.Semantic proximity Read ↗

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models.Semantic proximity Read ↗

Overview of Huntington's Disease Models: Neuropathological, Molecular, and Behavioral Differences.Semantic proximity Read ↗

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.Semantic proximity Read ↗

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.Semantic proximity Read ↗

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNASemantic proximity Read ↗

Temporal Phenotypic Changes in Huntington's Disease Models for Preclinical Studies.Semantic proximity Read ↗

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain.Semantic proximity Read ↗

Formation of polyglutamine inclusions in a wide range of non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington's disease.Semantic proximity Read ↗

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 miceSemantic proximity Read ↗

The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.