Article

Gene functions determine stochastic or adaptive futile transcription in cancers through deregulated start site deployments

2025-12-25

Abstract excerpt

<h4>Background</h4> Cancers display near–universal hallmarks, including energy addiction, aerobic glycolysis and biosynthesis. In addition to glucose (and glutamine) addiction, cancers also display futile transcription. Discretely measurable futile transcription occurs between transcription start sites (TSSs) and start codons of protein–coding genes. Multiple TSSs for each gene offer various combinations of futil...

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Literature Corpus work: 9796f4a0-8191-5102-a730-596a6d82c7cf
DOI: 10.64898/2025.12.22.696121

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