Article

A Spin-Glass Metabolic Hamiltonian optimized by Quantum Annealing Reveals Thermodynamic Phases of Cancer Metabolism

2026-04-07

Abstract excerpt

Understanding why specific metabolic states become stable in cancer has remained a fundamental challenge, as current pathway-centric frameworks lack a unifying physical principle governing global metabolic organization. We introduce the Metabolic Spin-Glass (MSG) model, which represents cellular metabolism using a thermodynamically informed effective Hamiltonian that integrates reference reaction free energies, co...

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Literature Corpus work: ae19040f-6f74-595d-a742-17011a229431
DOI: 10.64898/2026.04.05.715441

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