Article

Deep analysis of FANTOM CAGE data reveals hierarchical patterns of TSS co-deployment hubs and their disruption in cancers

2026-05-18

Abstract excerpt

Selective deployment of multiple transcription start sites is a major regulatory feature of human transcriptomes. FANTOM CAGE data exhibit a near-universal TSS deployment parsimony which is disrupted in cancers. We have recently shown that TSS deployment is sensitive to gene function, futile upstream transcription, and cellular biosynthetic states. Patterns in FANTOM CAGE data can reveal mechanisms underlying TSS...

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Literature Corpus work: d91fdf2a-6d88-5791-b4ee-5c6d10ba15d7
DOI: 10.64898/2026.05.15.725323

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