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Article

Surprisal analysis characterizes the free energy time course of cancer cells undergoing epithelial-to-mesenchymal transition.

Proceedings of the National Academy of Sciences of the United States of America - 9 Sept 2014

Zadran Sohila, Arumugam Rameshkumar, Herschman Harvey, Phelps Michael E, Levine R D

Abstract excerpt

The epithelial-to-mesenchymal transition (EMT) initiates the invasive and metastatic behavior of many epithelial cancers. Mechanisms underlying EMT are not fully known. Surprisal analysis of mRNA time course data from lung and pancreatic cancer cells stimulated to undergo TGF-β1-induced EMT identifies two phenotypes. Examination of the time course for these phenotypes reveals that EMT reprogramming is a multistep...

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Source

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Identifiers

PMID: 25157127
DOI: 10.1073/pnas.1414714111
PMCID: PMC4246928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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