Metastatic risk stratification of leiomyosarcoma patients using transcription- and replication-associated chromosomal instability mechanisms

Abstract excerpt

Leiomyosarcoma (LMS) is an aggressive smooth muscle cancer with few therapeutic options. LMSs show a high level of genomic instability (GI) and the mechanisms underlying their oncogenic processes are poorly understood. While the level of GI influences treatment efficacy and resistance, an accurate measure of it is lacking. Current measures of GI are based on counts of specific structural variation (SV) and mutatio...

Topics

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• Clonal Evolution
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• Genomics
• Leiomyosarcoma
• Muscle, Smooth
• RNA-Seq
• Survival Analysis

Identifiers and source

Literature Corpus work

9790f39d-5b2a-5278-8e2d-6e89343c8c72

DOI

10.1101/2021.01.29.21250218