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Article

Genomic Characteristics of Leiomyosarcoma: An AACR Project GENIE Study.

Anticancer research - 1 Jul 2026

Ali Henna, Chander Cinthiya, Torbenson Elijah, Hsia Beau, Silberstein Peter T

Abstract excerpt

BACKGROUND/AIM: Leiomyosarcoma is a rare and aggressive malignant smooth muscle tumor with limited treatment options and poor outcomes. Large-scale molecular characterization is needed to better understand tumor biology and support precision oncology, as prior studies have been limited by small cohort sizes, single-institution data, and restricted gene panels. This study aimed to characterize clinicogenomic...

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Source

Identifiers

PMID: 42373270
DOI: 10.21873/anticanres.18245

Genes

RB1
TP53
ATRX
AXIN1
IGF2
PTEN
ATM
BRCA2
FAT1
KMT2D
MAP2K4
MED12
NOTCH1
NOTCH3
ROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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