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Article

The Impact of Li-Fraumeni and Germline Retinoblastoma Mutations on Leiomyosarcoma Initiation, Outcomes, and Genetic Testing Recommendations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2024

Dermawan Josephine K, Abramson David H, Chiang Sarah, Hensley Martee L, Tap William D, Movva Sujana, Maki Robert G, Mandelker Diana, Antonescu Cristina R

Abstract excerpt

PURPOSE: Leiomyosarcomas (LMS) are clinically and molecularly heterogeneous, occurring mostly in sporadic but also syndromic settings. The role of pathogenic germline variants (PGV) as LMS drivers and their impact on outcomes remains uncertain. EXPERIMENTAL DESIGN: We performed a comprehensive clinicopathologic and molecular analysis using a tumor-normal DNA next-generation sequencing assay (Memorial Sloan...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39150540
DOI: 10.1158/1078-0432.CCR-24-1160
PMCID: PMC11479842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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