Back to search

Article

Beyond Mutation Count: Trinucleotide Spectrum Quality Stratifies Microsatellite-Stable Cancers Across Three Tumor Types

2026-07-30

Abstract excerpt

Microsatellite-stable (MSS) cancers comprise ~70% of patients but lack biomarkers to guide prognosis or therapy. Current metrics—TMB, CNV, and MSI—measure genomic instability quantity but discard sequence-context information encoding repair pathway activity. We developed the Trinucleotide Mutation Spectrum (TMS), a metric of mutation spectrum quality based on the proportional distribution of mutations across 192 t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
32e3dcac-d2d4-5183-aeca-022da948237e
DOI
10.20944/preprints202607.2203.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Beyond Mutation Count: Trinucleotide Spectrum Quality Stratifies Microsatellite-Stable Cancers Across Three Tumor TypesDOI 10.20944/preprints202607.2203.v1
TMScal: A Clinical Decision Support Tool for Prognostic Stratification of Microsatellite-Stable CancersSemantic proximity
Joint inference of mutational signatures from indels and single-nucleotide substitutions reveals prognostic impact of DNA repair deficiencies.Semantic proximity
pyCancerSig: subclassifying human cancer with comprehensive single nucleotide, structural and microsatellite mutational signature deconstruction from whole genome sequencingSemantic proximity
pyCancerSig: subclassifying human cancer with comprehensive single nucleotide, structural and microsatellite mutational signature deconstruction from whole genome sequencing.Semantic proximity
TruSight Oncology 500: Enabling Comprehensive Genomic Profiling and Biomarker Reporting with Targeted SequencingSemantic proximity
Accurate Microsatellite Instability Classification Using Ultima Genomics Platform Across Multiple Tumor TypesSemantic proximity
Reference-free microsatellite instability detection from tumor sequencing using intrasample variability modelingSemantic proximity
Genomic Landscape of Endometrial, Ovarian, and Cervical Cancers in Japan from the Database in the Center for Cancer Genomics and Advanced TherapeuticsSemantic proximity
Analytical Validation and Clinical Utilization of the Oncomine Comprehensive Assay Plus Panel for Comprehensive Genomic Profiling in Solid TumorsSemantic proximity
Genomic landscape of endometrial, ovarian and cervical cancers in Japan from database in the Center for Cancer Genomics and Advanced TherapeuticsSemantic proximity
Evaluating Multiple Next-Generation Sequencing–Derived Tumor Features to Accurately Predict DNA Mismatch Repair StatusSemantic proximity
A review on the Idylla platform: towards the assessment of actionable genomic alterations in one day.Semantic proximity
Select a neighboring publication to make it the new centre.