Article

Spatially-Resolved Multiomic Atlas of Leiomyosarcoma Identifies Two Clinically Relevant Epigenetically-Driven Cell States

2026-05-26

Abstract excerpt

<h4>ABSTRACT</h4> Leiomyosarcoma is a smooth muscle–derived malignancy marked by significant clinical heterogeneity. The extent and nature of cellular heterogeneity and molecular underpinnings remain poorly understood. To address this at transcriptomic and epigenomic levels, we performed single-nucleus multiome sequencing on untreated primary leiomyosarcoma tissues. Malignant cells segregated almost exclusively i...

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Literature Corpus work: a2706bdd-9bf5-5ede-a7d3-8b9f72826129
DOI: 10.64898/2026.05.22.726988

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