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Article

Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2024

Dermawan Josephine K, Chiang Sarah, Singer Samuel, Jadeja Bhumika, Hensley Martee L, Tap William D, Movva Sujana, Maki Robert G, Antonescu Cristina R

Abstract excerpt

PURPOSE: Leiomyosarcomas (LMS) are clinically and molecularly heterogeneous tumors. Despite recent large-scale genomic studies, current LMS risk stratification is not informed by molecular alterations. We propose a clinically applicable genomic risk stratification model. EXPERIMENTAL DESIGN: We performed comprehensive genomic profiling in a cohort of 195 soft tissue LMS (STLMS), 151 primary at presentation, and a...

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Source

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Identifiers

PMID: 38488807
DOI: 10.1158/1078-0432.CCR-24-0148
PMCID: PMC11096044

Genes

ATRX
RB1
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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