Article
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival.
Nature communications - 23 Jul 2021
Anderson Nathaniel D, Babichev Yael, Fuligni Fabio, Comitani Federico, Layeghifard Mehdi, Venier Rosemarie E, Dentro Stefan C, Maheshwari Anant, Guram Sheena, Wunker Claire, Thompson J Drew, Yuki Kyoko E, Hou Huayun, Zatzman Matthew, Light Nicholas, Bernardini Marcus Q, Wunder Jay S, Andrulis Irene L, Ferguson Peter, Razak Albiruni R Abdul, Swallow Carol J, Dowling James J, Al-Awar Rima S, Marcellus Richard, Rouzbahman Marjan, Gerstung Moritz, Durocher Daniel, Alexandrov Ludmil B, Dickson Brendan C, Gladdy Rebecca A, Shlien Adam
Abstract excerpt
Leiomyosarcomas (LMS) are genetically heterogeneous tumors differentiating along smooth muscle lines. Currently, LMS treatment is not informed by molecular subtyping and is associated with highly variable survival. While disease site continues to dictate clinical management, the contribution of genetic factors to LMS subtype, origins, and timing are unknown. Here we analyze 70 genomes and 130 transcriptomes of...
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