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Reciprocal regulation of the H <sub>3</sub> histamine receptor in Rett syndrome and <i>MECP2</i> Duplication syndrome: implications for therapeutic development

2025-10-31

Abstract excerpt

Rett syndrome (RTT) and MECP2 Duplication syndrome (MDS) are disorders caused by reciprocal decreases and increases in the expression of the transcriptional regulator, Methyl CpG Binding Protein 2 ( MeCP2 ). We previously performed an mRNA expression profiling study of the temporal cortex region from patients diagnosed with RTT and corresponding age, postmortem interval, and sex-matched controls. These studies...

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Literature Corpus work
977ab624-7604-53da-9a3f-3f2fd35d7783
DOI
10.1101/2025.10.30.685636
Open publication

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Reciprocal regulation of the H <sub>3</sub> histamine receptor in Rett syndrome and <i>MECP2</i> Duplication syndrome: implications for therapeutic developmentDOI 10.1101/2025.10.30.685636
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