Article
Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome.
Proceedings of the National Academy of Sciences of the United States of America - 28 Nov 2006
McGill Bryan E, Bundle Sharyl F, Yaylaoglu Murat B, Carson James P, Thaller Christina, Zoghbi Huda Y
Abstract excerpt
Rett syndrome (RTT), a postnatal neurodevelopmental disorder, is caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Children with RTT display cognitive and motor abnormalities as well as autistic features. We studied mice bearing a truncated Mecp2 allele (Mecp2(308/Y) mice) and found evidence of increased anxiety-like behavior and an abnormal stress response as evidenced by elevated serum...
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