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Ethanol‐Induced <scp><i>Htr3a</i></scp> Promoter Methylation Changes in Mouse Blood and Brain

26 Jul 2012

Abstract excerpt

BACKGROUND: Abnormal DNA methylation has been observed in promoter regions of a number of genes in human alcoholics. It is unclear whether DNA methylation changes in alcoholics result directly from alcohol consumption or predated the occurrence of alcohol abuse or dependence and whether altered DNA methylation influences gene expression. METHODS: We investigated ethanol (EtOH)-induced DNA methylation changes in...

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PMID: 22834954
DOI: 10.1111/j.1530-0277.2012.01906.x

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