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Article

Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance.

Nature communications - 4 Jan 2021

Bond Simon T, King Emily J, Henstridge Darren C, Tran Adrian, Moody Sarah C, Yang Christine, Liu Yingying, Mellett Natalie A, Nath Artika P, Inouye Michael, Tarling Elizabeth J, de Aguiar Vallim Thomas Q, Meikle Peter J, Calkin Anna C, Drew Brian G

Abstract excerpt

The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have been implicated in WAT lipid metabolism, including tripartite motif containing 28 (Trim28), a gene proposed to primarily influence adiposity via epigenetic mechanisms in embryonic development. However, in the current study we demonstrate that mice with deletion of Trim28 specifically in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33397965
DOI: 10.1038/s41467-020-20434-3
PMCID: PMC7782476

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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