Article
An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload.
International journal of molecular sciences - 3 Jul 2022
Ameka Magdalene K, Beavers William N, Shaver Ciara M, Ware Lorraine B, Kerchberger Vern Eric, Schoenfelt Kelly Q, Sun Lili, Koyama Tatsuki, Skaar Eric P, Becker Lev, Hasty Alyssa H
Abstract excerpt
Adipocyte iron overload is a maladaptation associated with obesity and insulin resistance. The objective of the current study was to determine whether and how adipose tissue macrophages (ATMs) regulate adipocyte iron concentrations and whether this is impacted by obesity. Using bone marrow-derived macrophages (BMDMs) polarized to M0, M1, M2, or metabolically activated (MMe) phenotypes, we showed that MMe BMDMs...
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