Article
Life without white fat: a transgenic mouse.
Genes & development - 15 Oct 1998
Moitra J, Mason M M, Olive M, Krylov D, Gavrilova O, Marcus-Samuels B, Feigenbaum L, Lee E, Aoyama T, Eckhaus M, Reitman M L, Vinson C
Abstract excerpt
We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2 enhancer/promoter. This protein prevents the DNA binding of B-ZIP transcription factors of both the C/EBP an...
Topics
- Adipose Tissue
- Adipose Tissue, Brown
- Amino Acid Sequence
- Animals
- CCAAT-Enhancer-Binding Proteins
- DNA-Binding Proteins
- Diabetes Mellitus, Experimental
- Fasting
- Female
- Leptin
- Leucine Zippers
- Male
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Nuclear Proteins
- Phenotype
- Proteins