Article
Integrative Molecular Characterization of Malignant Pleural Mesothelioma.
Cancer discovery - 1 Dec 2018
Hmeljak Julija, Sanchez-Vega Francisco, Hoadley Katherine A, Shih Juliann, Stewart Chip, Heiman David, Tarpey Patrick, Danilova Ludmila, Drill Esther, Gibb Ewan A, Bowlby Reanne, Kanchi Rupa, Osmanbeyoglu Hatice U, Sekido Yoshitaka, Takeshita Jumpei, Newton Yulia, Graim Kiley, Gupta Manaswi, Gay Carl M, Diao Lixia, Gibbs David L, Thorsson Vesteinn, Iype Lisa, Kantheti Havish, Severson David T, Ravegnini Gloria, Desmeules Patrice, Jungbluth Achim A, Travis William D, Dacic Sanja, Chirieac Lucian R, Galateau-Sallé Françoise, Fujimoto Junya, Husain Aliya N, Silveira Henrique C, Rusch Valerie W, Rintoul Robert C, Pass Harvey, Kindler Hedy, Zauderer Marjorie G, Kwiatkowski David J, Bueno Raphael, Tsao Anne S, Creaney Jenette, Lichtenberg Tara, Leraas Kristen, Bowen Jay, Felau Ina, Zenklusen Jean Claude, Akbani Rehan, Cherniack Andrew D, Byers Lauren A, Noble Michael S, Fletcher Jonathan A, Robertson A Gordon, Shen Ronglai, Aburatani Hiroyuki, Robinson Bruce W, Campbell Peter, Ladanyi Marc
Abstract excerpt
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of BAP1 alterations to date. We identified histology-independent molecular prognostic subsets, and defined a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of...
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