Article

Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models

2023-02-23

Abstract excerpt

<h4>ABSTRACT</h4> Euchromatic histone lysine methyltransferases 1 and 2 (EHMT1/2), which catalyze demethylation of histone H3 lysine 9 (H3K9me2), contribute to tumorigenesis and therapy resistance through unknown mechanisms of action. In ovarian cancer, EHMT1/2 and H3K9me2 are directly linked to acquired resistance to poly-ADP-ribose polymerase (PARP) inhibitors and are correlated with poor clinical outcomes. Usi...

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Literature Corpus work: fff35cb1-fb0b-5d93-8cb3-0ceee43c8b65
DOI: 10.1101/2023.02.23.529773

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