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Research Letter: Therapeutic targets for haemorrhoidal disease: proteome-wide Mendelian randomisation and colocalization analyses

2023-06-27

Abstract excerpt

Human haemorrhoidal disease (HEM) is a common anorectal pathology. However, the etiology of HEM, as well as its molecular mechanism, remains largely unclear. In this study, we applied a two-sample bi-direction Mendelian randomisation (MR) analysis to estimate the causal effects of 4907 plasma proteins on HEM outcomes and investigated the mediating impacts of plasma proteins on HEM risk factors to uncover potential...

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Literature Corpus work
97736b23-3a06-5c61-b4e6-49990cf0fba0
DOI
10.1101/2023.06.19.23291373
Open publication

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Research Letter: Therapeutic targets for haemorrhoidal disease: proteome-wide Mendelian randomisation and colocalization analysesDOI 10.1101/2023.06.19.23291373
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