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Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization study

3 Jun 2025

Abstract excerpt

BACKGROUND: The treatment of advanced or metastatic colorectal cancer (CRC) poses a global challenge. Mendelian Randomization (MR) has been primarily applied for repurposing licensed drugs and uncovering new therapeutic targets. OBJECTIVE: This study aims to systematically identify potential plasma protein targets for CRC using proteome-wide Mendelian randomization and evaluate their potential side effects...

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PMID: 40462010
DOI: 10.1186/s12014-025-09545-5

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