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Article

Finding Potential Drug Targets for Pre-Eclampsia Using Mendelian Randomisation and Colocalisation Analysis.

American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Mar 2025

Xu Yuexin, Pan Yingzi, Wu Chengqian, Zhao Tingting, Miao Jiayan, Ji Xiaohong

Abstract excerpt

INTRODUCTION: Pre-eclampsia (PE) is a common complication of pregnancy and there is an urgent need for new drug targets. We performed whole proteome-wide Mendelian randomisation (MR) and colocalisation analyses to identify potential therapeutic targets for PE. MATERIAL AND METHODS: A two-sample MR study was conducted using summary-level statistics of 734 plasma proteins retrieved from large genome-proteome-wide...

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PMID: 40028697
DOI: 10.1111/aji.70063

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