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3D-ΔΔG: A Dual-Channel Prediction Model for Protein-Protein Binding Affinity Changes Following Mutation Based on Protein 3D Structures.

Proteins - 1 Oct 2025

Wang Yuxiang, Zhu Yibo, Shi Xiumin, Wang Lu

Abstract excerpt

Protein-protein interactions are crucial for cellular regulation, antigen-antibody interactions, and other vital processes within living organisms. However, mutations in amino acid residues have the potential to induce changes in protein-protein binding affinity (ΔΔG), which may contribute to the onset and progression of disease. Existing methods for predicting ΔΔG use either protein sequence information or...

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PMID: 40375059
DOI: 10.1002/prot.26837

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