MuToN Quantifies Binding Affinity Changes upon Protein Mutations by Geometric Deep Learning.

Abstract excerpt

Assessing changes in protein-protein binding affinity due to mutations helps understanding a wide range of crucial biological processes within cells. Despite significant efforts to create accurate computational models, predicting how mutations affect affinity remains challenging due to the complexity of the biological mechanisms involved. In the present work, a geometric deep learning framework called MuToN is...

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