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Article

Enhancing mutation impact prediction in protein-protein interactions through interpretable graph-based multi-level feature interactions.

Bioinformatics (Oxford, England) - 7 Apr 2026

Wu Shiwei, Xu Nan, Xin Xiaohui, Zhang Min, Liu Haoliang, Zhu Hongjia, Wei Zhenyu, Zhao Chengkui, Yu Lei, Feng Weixing

Abstract excerpt

MOTIVATION: Protein-protein interactions (PPIs) are central to cellular functions, and predicting mutation-induced changes in binding affinity (ΔΔG) remains challenging. Although existing computational methods integrate sequence- and structure-derived features and thus implicitly capture certain sequence-structure relationships, they typically fuse these modalities through simple concatenation, without explicitly...

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PMID: 41902842
DOI: 10.1093/bioinformatics/btag150
PMCID: PMC13070472

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