PANDA: Predicting the change in proteins binding affinity upon mutations by finding a signal in primary structures.

Abstract excerpt

Accurately determining a change in protein binding affinity upon mutations is important to find novel therapeutics and to assist mutagenesis studies. Determination of change in binding affinity upon mutations requires sophisticated, expensive, and time-consuming wet-lab experiments that can be supported with computational methods. Most of the available computational prediction techniques depend upon protein...

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