Article

iPSC-Derived Hepatocytes from Patients with MASLD Exhibit Early Mitochondrial Dysfunction

2025-08-30

Abstract excerpt

<h4>Background: </h4> & Aims A hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD) is a decline in the ability of hepatocyte mitochondria to adapt to excess lipid. This leads to the production of reactive oxygen species (ROS) and the instigation of a vicious cycle of further mitochondrial damage and cellular dysfunction that promotes disease progression. In this study, we investigated whet...

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Literature Corpus work: cee04e68-fbbc-5e8b-9154-bb08c5ee4d7f
DOI: 10.1101/2025.08.27.672733

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