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Article

Lipid droplet accumulation drives glutamine-dependent NLRP3 inflammasome activation

2026-01-14

Abstract excerpt

The NLRP3 inflammasome is implicated in the pathogenesis of many inflammatory and metabolic diseases. Although metabolic cues can shape NLRP3 inflammasome activation, the role of lipid metabolism in this response is poorly understood. Lipids are essential for energy and redox homeostasis, membrane biogenesis, and diverse cellular processes. However, excessive accumulation of lipids such as free fatty acids can be...

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Literature Corpus work
95a7291c-8457-5607-b90f-8e9fbcfe0762
DOI
10.64898/2026.01.13.699337
Open publication

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Lipid droplet accumulation drives glutamine-dependent NLRP3 inflammasome activationDOI 10.64898/2026.01.13.699337
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