Article

Mitochondrial heteroplasmy is responsible for Atovaquone drug resistance in <i>Plasmodium falciparum</i>

2017-12-10

Abstract excerpt

Malaria is the most significant parasitic disease affecting humans, with 212 million cases and 429,000 deaths in 2 015 1 , and resistance to existing drugs endangers the global malaria elimination campaign. Atovaquone (ATO) is a safe and potent antimalarial drug that acts on cytochrome b (cyt. b) of the mitochondrial electron transport chain (mtETC) in Plasmodium falciparum, yet treatment failures result in res...

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Literature Corpus work: 975e8336-7c99-5978-8c75-76de35c2e2b3
DOI: 10.1101/232033

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