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Duplication of superoxide dismutase and a mutation in aquaglyceroporin mediates the sensitivity of <i>Plasmodium falciparum</i> to cryptosporin, a natural product derived from <i>Acaromyces ingoldii</i>

2026-06-10

Abstract excerpt

Cryptosporin, a fungal metabolite, exhibited potent antimalarial activity against both asexual blood stage Plasmodium falciparum and liver-stage Plasmodium berghei with minimal human HepG2 toxicity. Unlike atovaquone, cryptosporin’s mechanism is independent of mitochondrial electron transport. Minimum inoculum of resistance showed a low risk of resistance development. RNA-Seq analysis revealed the upregulation o...

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Literature Corpus work
0bdd5b8c-4812-5a4c-8970-c1abab5da7d5
DOI
10.64898/2026.06.08.730986
Open publication

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Duplication of superoxide dismutase and a mutation in aquaglyceroporin mediates the sensitivity of <i>Plasmodium falciparum</i> to cryptosporin, a natural product derived from <i>Acaromyces ingoldii</i>DOI 10.64898/2026.06.08.730986
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