Article
Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes.
Science (New York, N.Y.) - 15 Apr 2016
Goodman Christopher D, Siregar Josephine E, Mollard Vanessa, Vega-Rodríguez Joel, Syafruddin Din, Matsuoka Hiroyuki, Matsuzaki Motomichi, Toyama Tomoko, Sturm Angelika, Cozijnsen Anton, Jacobs-Lorena Marcelo, Kita Kiyoshi, Marzuki Sangkot, McFadden Geoffrey I
Abstract excerpt
Drug resistance compromises control of malaria. Here, we show that resistance to a commonly used antimalarial medication, atovaquone, is apparently unable to spread. Atovaquone pressure selects parasites with mutations in cytochrome b, a respiratory protein with low but essential activity in the mammalian blood phase of the parasite life cycle. Resistance mutations rescue parasites from the drug but later prove...
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