Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole genome sequencing identifies novel mutations in malaria parasites resistant to artesunate (ATN) and to ATN + mefloquine combination.

Frontiers in cellular and infection microbiology - 1 Jan 2024

Cassiano Gustavo Capatti, Martinelli Axel, Mottin Melina, Neves Bruno Junior, Andrade Carolina Horta, Ferreira Pedro Eduardo, Cravo Pedro

Abstract excerpt

Introduction: The global evolution of resistance to Artemisinin-based Combination Therapies (ACTs) by malaria parasites, will severely undermine our ability to control this devastating disease. Methods: Here, we have used whole genome sequencing to characterize the genetic variation in the experimentally evolved Plasmodium chabaudi parasite clone AS-ATNMF1, which is resistant to artesunate + mefloquine. Results...

Topics

Join the communities discussing this publication.

Antimalarials
Artesunate
Malaria, Falciparum
Mefloquine
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmodium falciparum

Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 38495651
DOI: 10.3389/fcimb.2024.1353057
PMCID: PMC10940360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole genome sequencing identifies novel mutations in malaria parasites resistant to artesunate (ATN) and to ATN + mefloquine combination.PMID 38495651Read ↗

Artemisinin resistance-associated gene mutations in Plasmodium falciparum: A case study of severe malaria from Mozambique.Semantic proximity Read ↗

Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falciparum confers resistance to artemisinin.Semantic proximity Read ↗

The genomic architecture of antimalarial drug resistanceSemantic proximity Read ↗

Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and EvolutionSemantic proximity Read ↗

Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa.Semantic proximity Read ↗

Peeling the onion: how complex is the artemisinin resistance genetic trait of malaria parasites?Semantic proximity Read ↗

Enhanced cell stress response and protein degradation capacity underlie artemisinin resistance in Plasmodium falciparum.Semantic proximity Read ↗

Drug resistance genomics of the antimalarial drug artemisininSemantic proximity Read ↗

Drug resistance in Plasmodium.Semantic proximity Read ↗

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistanceSemantic proximity Read ↗

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria.Semantic proximity Read ↗

Tackling resistance: emerging antimalarials and new parasite targets in the era of eliminationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.