Evolution of resistance in vitro reveals mechanisms of artemisinin activity in <i>Toxoplasma gondii</i>

Abstract excerpt

Artemisinins are effective against a variety of parasites and provide the first line of treatment for malaria. Laboratory studies have identified several mechanisms for artemisinin resistance in Plasmodium falciparum , including mutations in Kelch13 that are associated with delayed clearance in some clinical isolates, although other mechanisms are likely involved. To explore other potential mechanisms of...