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Evolution of resistance in vitro reveals mechanisms of artemisinin activity in <i>Toxoplasma gondii</i>

5 Dec 2019

Abstract excerpt

Artemisinins are effective against a variety of parasites and provide the first line of treatment for malaria. Laboratory studies have identified several mechanisms for artemisinin resistance in Plasmodium falciparum , including mutations in Kelch13 that are associated with delayed clearance in some clinical isolates, although other mechanisms are likely involved. To explore other potential mechanisms of...

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PMID: 31806760
DOI: 10.1073/pnas.1914732116

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