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Mitochondrial Drug Targets in Apicomplexan Parasites

31 Dec 2006

Abstract excerpt

In evolutionary terms, mitochondria in apicomplexan parasites appear to be "relicts-in-the-making": they possess the smallest mitochondrial genomes known, encoding only three proteins, and in one genus, Cryptosporidium, the genome is eliminated altogether. Several features of mitochondrial physiology provide validated or potential targets for antiparasitic drugs. Atovaquone, a broad spectrum antiparasitic drug,...

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PMID: 17266530
DOI: 10.2174/138945007779315632

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