Article
Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex.
Genome medicine - 6 Mar 2020
Merker Matthias, Kohl Thomas A, Barilar Ivan, Andres Sönke, Fowler Philip W, Chryssanthou Erja, Ängeby Kristian, Jureen Pontus, Moradigaravand Danesh, Parkhill Julian, Peacock Sharon J, Schön Thomas, Maurer Florian P, Walker Timothy, Köser Claudio, Niemann Stefan
Abstract excerpt
BACKGROUND: A comprehensive understanding of the pre-existing genetic variation in genes associated with antibiotic resistance in the Mycobacterium tuberculosis complex (MTBC) is needed to accurately interpret whole-genome sequencing data for genotypic drug susceptibility testing (DST). METHODS: We investigated mutations in 92 genes implicated in resistance to 21 anti-tuberculosis drugs using the genomes of 405...
Topics
- Antitubercular Agents
- Clofazimine
- Diarylquinolines
- Drug Resistance, Bacterial
- Genes, MDR
- Inhibitory Concentration 50
- Mutation
- Mycobacterium tuberculosis
- Phylogeny