Article
Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid.
Scientific reports - 30 Sept 2021
Gómez-González Paula J, Perdigao Joao, Gomes Pedro, Puyen Zully M, Santos-Lazaro David, Napier Gary, Hibberd Martin L, Viveiros Miguel, Portugal Isabel, Campino Susana, Phelan Jody E, Clark Taane G
Abstract excerpt
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the deadliest infectious diseases worldwide. Multidrug and extensively drug-resistant strains are making disease control difficult, and exhausting treatment options. New anti-TB drugs bedaquiline (BDQ), delamanid (DLM) and pretoma...
Topics
- Antitubercular Agents
- Diarylquinolines
- Drug Resistance, Multiple, Bacterial
- Humans
- Mutation
- Mycobacterium smegmatis
- Mycobacterium tuberculosis
- Nitroimidazoles
- Oxazoles
- Tuberculosis, Multidrug-Resistant
- Whole Genome Sequencing