Article
Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.
The Journal of antimicrobial chemotherapy - 1 Aug 2020
Kadura Suha, King Nicholas, Nakhoul Maria, Zhu Hongya, Theron Grant, Köser Claudio U, Farhat Maha
Abstract excerpt
BACKGROUND: Improved genetic understanding of Mycobacterium tuberculosis (MTB) resistance to novel and repurposed anti-tubercular agents can aid the development of rapid molecular diagnostics. METHODS: Adhering to PRISMA guidelines, in March 2018, we performed a systematic review of studies implicating mutations in resistance through sequencing and phenotyping before and/or after spontaneous resistance evolution,...
Topics
- Antitubercular Agents
- Clofazimine
- Diarylquinolines
- Humans
- Linezolid
- Microbial Sensitivity Tests
- Mutation
- Mycobacterium tuberculosis
- Nitroimidazoles
- Oxazoles