Article

Modelling hCDKL5 heterologous expression in bacteria

2021-06-17

Abstract excerpt

hCDKL5 refers to the human cyclin-dependent kinase that is primarily expressed in the brain where it exerts its function in several neuron districts. Mutations in its coding sequence are often causative of hCDKL5 deficiency disorder. The large-scale recombinant production of hCDKL5 is desirable to boost the translation of current therapeutic approaches into the clinic. However, this is hampered by the following fe...

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Literature Corpus work: 973d0287-f4eb-51db-9a1e-079cacb1d8da
DOI: 10.1101/2021.06.17.448472

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