A genome-based approach to create a minimally mutated Corynebacterium glutamicum strain for efficient L-lysine production.

Abstract excerpt

Based on the progress in genomics, we have developed a novel approach that employs genomic information to generate an efficient amino acid producer. A comparative genomic analysis of an industrial L-lysine producer with its natural ancestor identified a variety of mutations in genes associated with L-lysine biosynthesis. Among these mutations, we identified two mutations in the relevant terminal pathways as key...

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