Article

Optimal Protein Allocation Controls the Inhibition of GltA and AcnB in <i>Neisseria gonorrhoeae</i>

2024-05-26

Abstract excerpt

Neisseria gonorrhea (Ngo) is a major concern for global public health due to its severe implications for reproductive health. Understanding its metabolic phenotype is crucial for comprehending its pathogenicity. Despite Ngo’s ability to encode TCA cycle proteins, GltA and AcnB, their activities are notably restricted. To investigate this phenomenon, we used the iNgo_557 metabolic model and incorporated a constrain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 086a40ea-af2f-550b-9a3b-db244b5455c6
DOI: 10.1101/2024.05.22.595331

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Optimal Protein Allocation Controls the Inhibition of GltA and AcnB in <i>Neisseria gonorrhoeae</i>DOI 10.1101/2024.05.22.595331Read

Dinner date: Neisseria gonorrhoeae central carbon metabolism and pathogenesisSemantic proximity Read

Transcriptome guided metabolic network analysis reveals rearrangements of carbon flux distribution in <i>Neisseria gonorrhoeae</i> during neutrophil co-cultureSemantic proximity Read

A central role of sibling sRNAs NgncR_162/163 in main metabolic pathways of <i>Neisseria gonorrhoeae</i>Semantic proximity Read

Antibiotic resistance in Neisseria gonorrhoeae: broad-spectrum drug target identification using subtractive genomicsSemantic proximity Read

Genome-wide Core Proteome Analysis of Brucella melitensis Strains for Potential Drug Target PredictionSemantic proximity Read

Metabolic network models of <i>Gardnerella</i> pangenome identify interactions in the vaginal environmentSemantic proximity Read

Multi-omics profiling reveals atypical sugar utilization and identifies a key membrane composition regulator in <i>Streptococcus pneumoniae</i>Semantic proximity Read

Tapping the nucleotide pool of the host: novel nucleotide carrier proteins of <i>Protochlamydia amoebophila</i>Semantic proximity Read

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis.Semantic proximity Read

In silico Identification of Candidate Drug and Vaccine Targets from Various Pathways in Neisseria gonorrhoeaeSemantic proximity Read

Dual metabolomic profiling uncovers <i>Toxoplasma</i> manipulation of the host metabolome and the discovery of a novel parasite metabolic capabilitySemantic proximity Read

Impact of Active Metabolism on Chlamydia trachomatis Elementary Body Transcript Profile and InfectivitySemantic proximity Read