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Article

Reconstruction of a catalogue of genome-scale metabolic models with enzymatic constraints using GECKO 2.0.

Nature communications - 30 Jun 2022

Domenzain Iván, Sánchez Benjamín, Anton Mihail, Kerkhoven Eduard J, Millán-Oropeza Aarón, Henry Céline, Siewers Verena, Morrissey John P, Sonnenschein Nikolaus, Nielsen Jens

Abstract excerpt

Genome-scale metabolic models (GEMs) have been widely used for quantitative exploration of the relation between genotype and phenotype. Streamlined integration of enzyme constraints and proteomics data into such models was first enabled by the GECKO toolbox, allowing the study of phenotypes constrained by protein limitations. Here, we upgrade the toolbox in order to enhance models with enzyme and proteomics...

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Identifiers

PMID: 35773252
DOI: 10.1038/s41467-022-31421-1
PMCID: PMC9246944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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