Article

Profiles and Dynamics of the Transcriptome of Microglial Cells Reveal their Inflammatory Status

2021-12-21

Abstract excerpt

The primary role of microglia in the maintenance of brain homeostasis is to respond to disturbances in the microenvironment. In this study, we cultured murine neonatal microglia and activated them with lipopolysaccharide (LPS) and benzoyl ATP (bzATP) to characterize changes in the transcriptome in response to various in vivo stimuli caused by pathogens, injury, or toxins. Activation by bzATP, an agonist of purine...

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Literature Corpus work: 973ca76f-9751-5367-9391-b4caa2a07ddf
DOI: 10.1101/2021.12.20.473548

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