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Article

Phenotyping primary human microglia: tight regulation of LPS responsiveness.

Glia - 1 Oct 2012

Melief Jeroen, Koning Nathalie, Schuurman Karianne G, Van De Garde Martijn D B, Smolders Joost, Hoek Robert M, Van Eijk Marco, Hamann Jörg, Huitinga Inge

Abstract excerpt

Much is still unknown about mechanisms underlying the phenotypical and functional versatility of human microglia. Therefore, we developed a rapid procedure to isolate pure microglia from postmortem human brain tissue and studied their immediate ex vivo phenotype and responses to key inflammatory mediators. Microglia were isolated, along with macrophages from the choroid plexus by tissue dissociation, density...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22740309
DOI: 10.1002/glia.22370

Genes

CCL18
CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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