Article

Transcriptional Waves Induced by ATP and LPS in Primary Microglial Culture Reveal Multiple Inflammatory States

2022-02-28

Abstract excerpt

The primary role of microglia is to respond effectively to various disturbances to maintain brain homeostasis. In this study, we stimulated murine neonatal microglial cells with benzoyl ATP (bzATP) and lipopolysaccharide (LPS) and monitored their ability to secrete pro-inflammatory cytokines together with the changes in the transcriptome of the culture. Activation by bzATP, an agonist of purinergic receptors, indu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 064fa5a3-d037-5c34-a129-061df1edc6d6
DOI: 10.21203/rs.3.rs-1359348/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptional Waves Induced by ATP and LPS in Primary Microglial Culture Reveal Multiple Inflammatory StatesDOI 10.21203/rs.3.rs-1359348/v1Read

Profiles and Dynamics of the Transcriptome of Microglial Cells Reveal their Inflammatory StatusSemantic proximity Read

PPARδ activation in microglia drives a transcriptional response that primes phagocytic function while countering inflammatory activationSemantic proximity Read

Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNSSemantic proximity Read

The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis.Semantic proximity Read

Glucose pathways adaptation supports acquisition of activated microglia phenotype.Semantic proximity Read

Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ.Semantic proximity Read

Cultured human adult microglia from different donors display stable cytokine, chemokine and growth factor gene profiles but respond differently to a pro-inflammatory stimulus.Semantic proximity Read

Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain InjurySemantic proximity Read

Tumor necrosis factor α-induced protein 8-like-2 controls microglia phenotype via metabolic reprogramming in BV2 microglial cells and responses to neuropathic pain.Semantic proximity Read

Prior hypoxia exposure enhances murine microglial inflammatory gene expression <i>in vitro</i> without concomitant H3K4me3 enrichmentSemantic proximity Read

Analysis of differentially expressed long noncoding RNAs in LPS-induced human HMC3 microglial cellsSemantic proximity Read

Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12Semantic proximity Read