Article

Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strain

2022-08-25

Abstract excerpt

<h4>Summary</h4> The Omicron variant of SARS-CoV-2 evades neutralization by most serum antibodies elicited by two doses of mRNA vaccines, but a third dose of the same vaccine increases anti-Omicron neutralizing antibodies. By combining computational modeling with data from vaccinated humans we reveal mechanisms underlying this observation. After the first dose, limited antigen availability in germinal centers res...

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Literature Corpus work: 972bc826-37d1-5ca4-aca2-09661c42ec92
DOI: 10.1101/2022.08.24.505127

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